Tocolytic therapy

What are the tocolytic drugs?

The most common tocolytic agents used for the treatment of preterm labor are magnesium sulfate ( MgSO4 ), indomethacin , and nifedipine .

What is Tocolytic therapy used for?

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions ( TOCOLYSIS ). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists.

Which drugs are used to suppress preterm labor?

Doctors may try to stop or delay preterm labor by administering a medication called terbutaline ( Brethine ). Terbutaline is in a class of drugs called betamimetics . They help prevent and slow contractions of the uterus. It may help delay birth for several hours or days.

What is the goal of tocolytic therapy in preterm labor?

Tocolytic agents have not proven to be efficacious in preventing preterm birth or reducing neonatal mortality or morbidity. The primary purpose of tocolytic therapy today is to delay delivery for 48 hours to allow the maximum benefit of glucocorticoids to decrease the incidence of RDS.

Is nifedipine a Tocolytic?

CONCLUSION. Nifedipine appears to be superior to β2-adrenergic-receptor agonists and magnesium sulfate and should be considered as the first-line tocolytic agent for the management of preterm labor.

Is brethine a Tocolytic?

Terbutaline , sold under the brand name Bricanyl among others, is a β2 adrenergic receptor agonist, used as a “reliever” inhaler in the management of asthma symptoms and as a tocolytic (anti-contraction medication) to delay preterm labor for up to 48 hours.

Is oxytocin a Tocolytic?

Since oxytocin induces contractions, the inhibition of its action has been a target in the management of preterm labor. Atosiban is today the only oxytocin receptor antagonist that is available as a tocolytic .

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Is progesterone a Tocolytic?

Progesterone , which has been used in the prevention of preterm birth for over 10 years, has long been known to have the effect of uterine quiescence. It was first studied as a tocolytic agent in the 1960s.

Is MgSO4 a Tocolytic?

Serum magnesium levels are reported and the use of MgSO4 in patients with significant vaginal bleeding is discussed. MgSO4 was found to be a successful, inexpensive, and relatively nontoxic tocolytic agent that had few side effects.

Can premature birth stop?

Preterm birth can ‘t always be prevented . But moms-to-be can help lower their chances of going into labor too soon. Here’s the best advice: See your doctor early and regularly in your pregnancy for prenatal care.

Does magnesium stop labor?

Magnesium sulfate is often quite effective in slowing contractions, although this effect and how long it lasts varies from woman to woman. Like all tocolytic medications, however, magnesium sulfate does not consistently prevent or delay preterm delivery for a significant period of time.

Does bed rest prevent preterm labor?

There is no evidence that long-term bed rest lowers the risk of preterm delivery. Studies have shown that strict bed rest for 3 days or more may raise your risk of getting a blood clot in the legs or lungs. Strict bed rest is no longer used to prevent preterm labor .

How do you manage preterm labor?

There are three kinds of medicines your provider may give you if you’re having preterm labor: Antenatal corticosteroids (also called ACS). These speed up your baby’s lung development. Antibiotics . These kill infections caused by bacteria. Tocolytics. These slow or stop labor contractions.

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How does indomethacin work for preterm labor?

NSAIDs can prevent the body from releasing prostaglandins and cytokines, and as a result, delay preterm delivery when given at the onset of preterm labor .

How is preterm labor treated?

Treatment for preterm labor may include: Bed rest . This can be done either at home or in the hospital. Tocolytic medicines. These help slow or stop contractions. Corticosteroids . These may help the lungs of your baby grow and mature. Cervical cerclage. Antibiotics . Delivery of the baby.

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