What is lutetium therapy?
Lutetium -177 PSMA (Prostate Specific Membrane Antigen) is an innovative therapy used to treat metastatic castration resistant prostate cancer. The therapy works to reduce the tumour size and prevents the tumour from increasing, whilst also helping to improve the symptoms that these tumours might cause.
How is lutetium used in cancer therapy?
Lutetium is a radiation-based treatment that utilizes a molecule to attach itself to the PSMA receptors located on the cancer cells. Lutetium -177 emits beta radiation that effectively damages cancer cells and, over time, destroys them.
What type of radiation does lutetium emit?
Lutetium -177 is a medium-energy beta-emitter with a half-life of 6.7 days and a maximum energy of 0.5 MeV (maximum soft-tissue penetration of 2 mm).
Is Prrt chemotherapy?
As a result, PRRT typically has milder side effects compared with chemotherapy . PRRT is a treatment option that is highly effective in controlling advanced, progressive neuroendocrine tumors. PRRT is not curative, but has been shown to help relieve symptoms and slow the progression of the disease.
Does the human body use lutetium?
Lutetium has no biological role but is said to stimulate the metabolism.
How much does lutetium cost?
Pure lutetium metal is very difficult to prepare. It is one of the rarest and most expensive of the rare earth metals with the price about US$10,000 per kilogram, or about one-fourth that of gold.
Is lutetium dangerous?
Lutetium is mildly toxic by ingestion , but its insoluble salts are non-toxic. Like other rare-earth metals lutetium is regarded as having a low toxicity rating but it and its compounds should be handled with care.
Where is lutetium commonly found?
Lutetium is never found in nature as the free element. Lutetium is found in the ores monazite sand [(Ce, La, etc.) PO4] and bastn°site [(Ce, La, etc.)( Abundances of lutetium in various environments.
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What is lutetium used for in everyday life?
Lutetium and its compounds have found some applications, the most important of these is the use of the oxide in making catalysts for cracking hydrocarbons in the petrochemical industry. But there are other more specialist uses , such as using the radioactive Lutetium -177 isotope in cancer therapy.
What type of radiation does lutetium 177 emit?
Lu – 177 emits β-rays that have a short range in soft tissue (average 0.23 mm, max. 1.7 mm) and γ-rays. The radionuclide is produced by the Lu -176(n,γ) Lu – 177 reaction.
How is lutetium 177 produced?
The 177Lu production processes are based on irradiation of isotopically enriched 176 Lu or 176Yb with reactor neutrons, followed by radiochemical processing of the irradiated targets. Specific production features are analyzed with emphasis on process aspects of the reactor and radiochemical stages.
Who makes Lutathera?
Lutathera ® (lutetium Lu 177 dotatate) is a peptide receptor radionuclide therapy (PRRT) indicated for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumours. The drug was discovered and developed by Advanced Accelerator Applications, a Novartis company.
Can neuroendocrine tumors be cured?
When completely removing the tumor is not possible, debulking surgery is sometimes recommended. Debulking surgery removes as much of the tumor as possible and may provide some relief from symptoms, but it generally does not cure a NET.
How many Prrt treatments can you have?
How is PRRT performed? The most common protocol, which is the basis of the FDA and European Medicines Agency approval, includes a series of four PRRT treatments with 177Lu-DOTATATE spaced approximately two months apart.
What are the side effects of Prrt treatment?
What are the potential side effects? The infusion of amino acids in PRRT helps decrease the amount of radiation the kidneys receive, but it may cause nausea and vomiting , which is typically managed with anti- nausea medication.