Artemisinin combination therapy

What is artemisinin based combination therapy?

falciparum malaria, is artemisinin – based combination therapy ( ACT ). The primary objective of treatment is to ensure the rapid and full elimination of Plasmodium parasites from a patient’s bloodstream in order to prevent an uncomplicated case of malaria from progressing to severe disease or death.

Why is artemisinin used in combination therapy?

ACTs combine an artemisinin derivative1 with a partner drug. The role of the artemisinin compound is to reduce the number of parasites during the first 3 days of treatment (reduction of parasite biomass), while the role of the partner drug is to eliminate the remaining parasites (cure).

What are the various composition of artemisinin based combinations on the market?

Fast acting artemisinin – based compounds are combined with a drug from a different class. Companion drugs include lumefantrine, mefloquine, amodiaquine, sulfadoxine/pyrimethamine, piperaquine and chlorproguanil/dapsone. Artemisinin derivatives include dihydroartemisinin, artesunate and artemether.

Is Artemisinin safe to take?

* Artemisinin -containing therapies generally are considered safe , effective, and well-tolerated medications for the treatment of malaria caused by P. falciparum with no major side effects (2–4).

Is artemisinin an antiviral?

In in vitro studies, several groups have reported that artemisinins have antiviral properties. Artemisinins reduce replication rates of hepatitis B and C viruses [91,92], a range of human herpes viruses [93–95], HIV-1 [96], influenza virus A [93,97] and a bovine viral diarrhoea virus [98] in the low micromolar range.

What are the side effects of artemisinin?

Some common side effects of artemisinin are: skin rash . nausea . vomiting . tremors . liver issues.

How long does artemisinin stay in the body?

It is a combination drug of two ingredients, neither of which has been approved in the U.S. One is artemether, a chemical derivative of artemisinin , an extract from the sweet wormwood bush that was used in Chinese medicine as a fever cure for 500 or 600 years. Artemether stays in the body for three days.

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How do you use artemisinin?

Some people use 4.5 to 9 grams of the dried Artemisia annua herb in boiling water as a tea infusion to help treat fever and malaria. Others use 100 to 200 milligrams of artemisinin , in combination with other therapies, to treat the disease.

Why is Artemisia banned?

In fact since two thousand years and among thousands of people using the herbal tea against malaria, the phenomena of resistance has never been established. It was also insinuated that Artemisia annua could contain toxic substances, which led in Belgium to a law in 1998 prohibiting the Artemisia annua herbal tea.

What does artemisinin mean?

Artemisinin is an antimalarial lactone derived from qinghao (青蒿, Artemisia annua or sweet wormwood). The medicinal value of this plant has been known to the Chinese for at least 2,000 years. In 1596, Li Shizhen recommended tea made from qinghao specifically to treat malaria symptoms in his Compendium of Materia Medica.

Which is the best malaria drug in Nigeria?

Artesunate Is the Best Choice for the Severe and Complicated Malaria Therapy.

How does Artemisinin kill malaria?

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome | Nature Communications.

What are the benefits of artemisinin?

Artemisinin has been widely used for the treatment of malaria for the past two decades [4]. Additionally, artemisinin is known to have antibacterial, antifungal, antileishmanial, antioxidant , antitumor, and anti-inflammatory activity [5,6,7].

What is the best artemisinin?

Doctor’s Best Artemisinin contains high quality Artemisinin or Ching-hao-su, an extract from the traditional Chinese herb artemisia annua ( sweet wormwood ) or Ching-hao. Sweet wormwood leaves have been consumed over several centuries for promoting general health.

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Is artemisinin an antibiotic?

Artemisinin , one of the bioactive compounds, with antimalarial activity has been successfully isolated from A. annua [4]. Other than antimalarial activity, artemisinin was found to be a good antibacterial , antifungal, antileishmanial, and antitumor agent.

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